Nucleic acid molecules for pseudouridylation
US11866702B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Mar 27, 2019 |
| Grant date | Jan 9, 2024 |
| Priority date | — |
| Expiry date | Jun 18, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/335
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.