Fusion proteins comprising enzyme replacement therapy enzymes

US11866742B2 · kind B2 · utility

Assignee

• DENALI THERAPEUTICS INC. · US

Inventors

• Anastasia Henry · South San Francisco, US
• Mihalis Kariolis · South San Francisco, US
• Cathal S. Mahon · San Francisco, US
• Adam P. Silverman · South San Francisco, US
• Ankita Srivastava · Mumbai, IN
• Julie Ullman · San Francisco, US

Key dates

• Filing date: Nov 23, 2020
• Grant date: Jan 9, 2024
• Expiry date: Nov 16, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y310/01001
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.