Controlled doping of anodic aluminum oxide for enhanced fluorescence and methods of preparation
US11867633B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Feb 24, 2020 |
| Grant date | Jan 9, 2024 |
| Priority date | — |
| Expiry date | May 18, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/6439
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Nano-structured anodic aluminum oxide ceramic films and membranes doped with chelated metals for fluorescence enhancement. Controlled doping during production steps results in the inclusion of traces of ions in the finished materials while maintaining high control over the film structure. This approach yields products suitable for optical applications, including fluorescence enhancement. The nano-structured anodic aluminum oxide ceramic films and membranes are particularly useful for in vitro diagnostics, drug discovery, DNA sequencing, proteomics, immunofluorescence, immunohistochemistry, biosensing, and bio-assay fluorescence technologies such as time resolved Forster resonance energy transfer (TR-FRET), Fluorescence in situ hybridization (FISH), Fluorescence-lifetime imaging microscopy (FLIM), Fluorescence polarization immunoassay (FPIA), Fluorescence anisotropy or fluorescence polarization, Fluorescence recovery after photobleaching (FRAP), Fluorescence Loss in Photobleaching (FLIP), Fluorescence correlation spectroscopy (FCS), and Falck-Hillarp fluorescence (F-H).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.