Site-specific antibody-drug glyconjugates and methods
US11872215B2 · kind B2 · utility
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22Claims
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Key dates
| Filing date | Jan 22, 2021 |
| Grant date | Jan 16, 2024 |
| Priority date | — |
| Expiry date | Apr 3, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds, compositions, and methods are provided for covalently linking an antibody or an antibody fragment to a cargo molecule, such as a therapeutic or a diagnostic agent, using a combination of enzymatic glycan remodeling and click chemistry. The method allows a cargo molecule to be selectively and efficiently attached post-translationally to an antibody or an antibody fragment. Also provided are antibody drug conjugates, methods of making, and uses thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.