Pyrazole compounds and preparation thereof

US11873289B2 · kind B2 · utility

Assignee

• MyoKardia, Inc. · US

Inventors

• Sunil Sharma · Salt Lake City, US
• Dinesh Jangid · Bhangrola, IN
• Priyanka Dhaka · Bhangrola, IN
• Siddharth Madhwal · Bhangrola, IN
• Bharat Kumar · Tarrytown, US
• Kapil Kumar · Barwala, IN
• Rajdeep Anand · Barwala, IN
• Anurag Jain · Barwala, IN

Key dates

• Filing date: Feb 1, 2019
• Grant date: Jan 16, 2024
• Expiry date: Feb 1, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides processes for preparation of substituted pyrazole compounds of formula II, that can be used as intermediates for preparation of substituted piperidine urea compounds useful for the treatment of dilated cardiomyopathy (DCM). R2 is independently selected from F, C1-C4 alkyl, C1-C4 haloalkyl, R3 is independently selected from H, F, C1-C4 alkyl, C1-C4 haloalkyl, R4 is C1-C4 alkyl, R6 is H or a protecting group and R7 is selected from H, CI or trialkylsilyl.