Trans-indoline cyclopropylamine chemical compound, and method for preparation, pharmaceutical composition, and use thereof

US11873292B2 · kind B2 · utility

Assignee

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Hong Liu · Shanghai, CN
• Jia-He Li · Cockeysville, US
• Wei Zhu · Shanghai, CN
• Yubo Zhou · Shanghai, CN
• Jiang Wang · Shanghai, CN
• Mingbo Su · Shanghai, CN
• Shuni Wang · Shanghai, CN
• Wei Xu · Saginaw, US
• Chunpu Li · Qingdao, CN
• Weijuan KAN · Shanghai, CN
• Hualiang Jiang · Shanghai, CN
• Kaixian Chen · Shanghai, CN

Key dates

• Filing date: Jun 2, 2017
• Grant date: Jan 16, 2024
• Expiry date: Feb 21, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to the fields of medicinal chemistry and pharmacotherapy, and specifically relates to the chemical compound of formula (I), and its racemate, R-isomer, S-isomer, pharmaceutically acceptable salt, and mixtures thereof, as well as its method for preparation, a pharmaceutical composition containing said chemical compound, and use as a lysine-specific demethylase 1 (LSD 1) inhibitor. The cyclopropylamine chemical compound to which the present invention relates may be used in the treatment of cancer.