Preserving spatial-proximal contiguity and molecular contiguity in nucleic acid templates
US11873481B2 · kind B2 · utility
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Key dates
| Filing date | Nov 20, 2018 |
| Grant date | Jan 16, 2024 |
| Priority date | — |
| Expiry date | Feb 8, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6869
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are methods and compositions for preparing nucleic acid templates wherein spatial-proximal and molecular contiguity of target nucleic acids is preserved, and the sequencing data obtained therefrom is used, but not limited to, identification of genomic variants, determination of contiguity information to inform assemblies of target nucleic acids de novo including deconvolution of haplotype phase information, and analyses of conformation and topology of target nucleic acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.