Aconitic acid exporter (aexA) increases organic acid production in Aspergillus
US11873523B2 · kind B2 · utility
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Key dates
| Filing date | Jun 14, 2021 |
| Grant date | Jan 16, 2024 |
| Priority date | — |
| Expiry date | Jun 14, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/69
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Recombinant Aspergillus genetically modified to increase expression of g8846, renamed herein as aconitic acid exporter (aexA), are provided, which in some examples are also genetically inactivated for an endogenous cis-aconitic acid decarboxylase (cadA) gene. Such recombinant Aspergillus produce more aconitic acid as compared to native Aspergillus. Also provided are methods of using such recombinant Aspergillus to increase production of aconitic acid and other organic acids, such as citric acid, itaconic acid, and 3-hydroxypropionic acid (3-HP).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.