Methods for the evaluation of system inertness
US11874256B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 10, 2021 |
| Grant date | Jan 16, 2024 |
| Priority date | — |
| Expiry date | Nov 27, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/889
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample including a positive (e.g., metal reacting moiety) control into the system. Some methods can include: (1) repeatedly injecting the sample into a system, the system comprising: fluidic paths wherein interior surfaces of the fluidic paths define wetted surfaces, and wherein at least a portion of the wetted surfaces of the fluidic flow path are coated with an inert coating, wherein the inert coating is inert to at least one analyte in the sample; (2) detecting a value associated with the positive control; and (3) analyzing values associated with the detected positive control to determine system inertness.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.