Crystalline forms of 1-(4-{[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methyl}-4-fluoro-piperidin-1-yl)-propenone, salt forms thereof, and processes to obtain

US11878967B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Michael Lange · Darmstadt, DE
• Clemens Kuehn · Darmstadt, DE
• Tobias Schlueter · Weiterstadt, DE
• Werner Mederski · Zwingenberg, DE
• David Maillard · Coventry, GB
• Edoardo Burini · Guidonia, IT

Key dates

• Filing date: Jun 17, 2019
• Grant date: Jan 23, 2024
• Expiry date: Dec 13, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A solid form of 1-(4-{[6-Amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methy}-4-fluoro-piperidin-1-yl)-propenone, or pharmaceutically acceptable salts thereof, is useful as a BTK inhibitor.