Bicyclic compounds and their uses

US11878973B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Vincent BORDAS · Village-Neuf, FR
• Jvan BRUN · Muttenz, CH
• Markus Furegati · Allschwil, CH
• Jacques Hamon · Orsay, FR
• Jürgen Hans-Hermann HINRICHS · Schopfheim, DE
• Philipp Holzer · Sissach, CH
• Fatma LIMAM · Strasbourg, FR
• Henrik MÖBITZ · Freiburg (Elbe), DE
• Sandro NOCITO · Wölflinswil, CH
• Simone PLATTNER · Weil am Rhein, DE
• Niko Schmiedeberg · Riehen, CH
• Joseph Schoepfer · Riehen, CH
• Ross Sinclair Strang · Ramsgate, GB
• Frederic Zecri · Cambridge, US

Key dates

• Filing date: May 25, 2022
• Grant date: Jan 23, 2024
• Expiry date: May 25, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I): wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.