Antibodies or antigen-binding fragments that bind to OX40

US11879015B2 · kind B2 · utility

Assignee

• BIODURO (BEIJING) CO., LTD. · CN

Inventors

• Xiang Li · Danbury, US
• Guoqian Sun · Beijing, CN
• Chenguang Cai · Beijing, CN
• Shiying Fu · Beijing, CN
• Ting Yang · Shanghai, CN
• Shuang Zhao · Ann Arbor, US
• Ying Li · Millburn, US
• Xinyue Dai · Beijing, CN
• Qi Sun · Beijing, CN
• Fengzhi Zhang · Beijing, CN
• Youyou Lin · Beijing, CN
• Yu Chen · Foster City, US
• Zhengfei Xue · Beijing, CN
• Hui PANG · Taizhou City, CN
• Ying Bai · Beijing, CN
• Shin-Chen Hou · Beijing, CN

Key dates

• Filing date: Apr 29, 2022
• Grant date: Jan 23, 2024
• Expiry date: Apr 29, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides antibodies that bind to OX40 and antigen binding fragments thereof, and use of the antibodies and the antigen binding fragments in the treatment of diseases for example cancers. The antibodies or the antigen binding fragments include a heavy chain variable region including one or more CDRs having an amino acid sequence selected from amino acid sequences as set forth in SEQ ID NOs: 1-12.