Hepatic inflammation analysis with dynamic PET
US11883223B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 15, 2019 |
| Grant date | Jan 30, 2024 |
| Priority date | — |
| Expiry date | Jan 22, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30056
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A system and method for determining kinetic parameters associated with a kinetic model of an imaging agent in a liver is provided. An image reconstruction device can receive radiotracer activities corresponding to a predetermined time period. For example, these radiotracer activities can include PET scan data corresponding to a number of time frames. The radiotracer activities can be used to determine a liver time activity curve and a circulatory input function. The liver time activity curve and circulatory input function can be used along with a kinetic model of the liver to produce kinetic parameters. These kinetic parameters can be used to determine hepatic scores, such as a hepatic steatosis score, a hepatic inflammation score, and a cirrhosis score. These scores are indicative of diseases of the liver, including nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and hepatic fibrosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.