6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors

US11883367B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Tongfei Wu · Leuven, BE
• Dirk Brehmer · Glückstadt, DE
• Lijs Beke · Ekeren, BE
• An Boeckx · Herentals, BE
• Gaston Stanislas Marcella Diels · Turnhout, BE
• Ronaldus Arnodus Hendrika Joseph Gilissen · Beerse, BE
• Edward C. Lawson · Pipersville, US
• Vineet Pande · Vosselaar, BE
• Marcus Cornelis Bernardus Catharina Paradé · Eindhoven, NL
• Wim Bert Griet Schepens · Sint-Katelijne-Waver, BE
• Johannes Wilhelmus John F. Thuring · Ekeren, BE
• Marcel Viellevoye · Breda, NL
• Weimei Sun · North Wales, US
• Lieven Meerpoel · Beerse, BE

Key dates

• Filing date: Mar 9, 2022
• Grant date: Jan 30, 2024
• Expiry date: Mar 9, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.