Patent · US Active

Algal botanical extracts rich in eicosapentaenoic acid as tri/di-glyceride conjugate

US11883377B1 · kind B1 · utility

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Key dates

Filing dateNov 25, 2022
Grant dateJan 30, 2024
Priority date—
Expiry dateNov 27, 2042

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K2236/333
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Botanical extracts are provided, which comprise ethanol extracts of Nannochloropsis algae having between 1 wt % and 50 wt % polar lipids and between 45 wt % and 60 wt % fatty acids, wherein the fatty acids comprise more than 10 wt % of eicosapentaenoic acid (EPA) as triglyceride conjugates and/or diglyceride conjugates, and less than 15 wt % EPA as free fatty acids. EPA level may reach up to 90 wt %, and the botanical extract may be fluid at room temperature. Growth conditions are configured, adjusted and monitored to promote EPA formation in the cell vacuoles, resulting in a high proportion of EPA as tri/di-glyceride conjugates, as well as in a high concentration of Ω-3 fatty acids, which merely requires gentle extraction procedures to reach the final products, thereby maintaining the biochemical of the compounds without excessive modifications.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.