ASH1L inhibitors and methods of treatment therewith

US11883381B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Jolanta Grembecka · Ann Arbor, US
• Tomasz Cierpicki · Ann Arbor, US
• David Rogawski · Ann Arbor, US
• Dmitry Borkin · Ann Arbor, US
• Szymon Klossowski · Ann Arbor, US
• Zhuang Jin · West Palm Beach, US
• Deanna Montgomery · Ann Arbor, US
• Jing Deng · Ann Arbor, US
• Marta Krotoska · Ann Arbor, US
• Hao Li · Brookline, US

Key dates

• Filing date: May 12, 2017
• Grant date: Jan 30, 2024
• Expiry date: May 12, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.