DNA polymerase gamma inhibitor and uses thereof
US11883419B2 · kind B2 · utility
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Key dates
| Filing date | Jun 25, 2018 |
| Grant date | Jan 30, 2024 |
| Priority date | — |
| Expiry date | Feb 27, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC09B35/025
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pol γ protein inhibitor compounds are useful for selectively inhibiting the growth of MLH1 mutant/deficient tumor or cancer cells due to a synthetic lethal relationship between MLH1 and Pol γ. The compounds were shown to directly interact with Pol γ and inhibit its biological function and cause cancer cell death and an inhibition of tumor or cancer cell growth in multiple assays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.