Tunable, controlled-release, urethane-containing elastomers and processes of forming the same

US11883557B2 · kind B2 · utility

Assignee

• THE SECANT GROUP, LLC · US

Inventors

• Stephanie M. Reed · Conshohocken, US
• Carissa SMOOT · Harleysville, US
• Dennis Shull · Phoenixville, US
• Todd Crumbling · Perkasie, US
• John D'Ottavio · Telford, US
• Peter D. GABRIELE · Bristol, US
• Jeremy J. HARRIS · Doylestown, US
• Charles Brendan NICHOLSON · Coopersburg, US
• Jared Ely · Quakertown, US

Key dates

• Filing date: May 9, 2022
• Grant date: Jan 30, 2024
• Expiry date: May 9, 2042

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B33Y10/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.