System and method for selecting and culturing cells

US11883575B2 · kind B2 · utility

Assignee

• Fenwal, Inc. · US

Inventors

• Christopher J. Wegener · Libertyville, US
• Bret M. Olson · Kalamazoo, US
• Alaina Schlinker · Chicago, US
• Steven Binninger · Frankfurt am Main, DE
• Avnie A. Kadakia · Chicago, US
• Kyle Thompson · Vernon Hills, US
• Kyle Wolok · Chicago, US
• Melanie Hamilton · Glenview, US

Key dates

• Filing date: Sep 19, 2019
• Grant date: Jan 30, 2024
• Expiry date: Nov 16, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/54366
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A cell processing system includes at least one processor connectable to a source container filled with a biological fluid, the processor including a spinning membrane configured to receive and separate target cells from the biological fluid, the target cells exiting at a first outlet, first and second containers selectively connected to the first outlet; and a magnet. The system also includes a controller configured to operate the spinning membrane to receive biological fluid and to direct the target cells to the first container, to pause to permit magnetic particles to be associated with the target cells in the first container, to operate the spinning membrane to receive the contents of the first container with the magnet applied to the target cells associated with the magnetic particles, to remove or deactivate the magnet, and to transfer the target cells to the second container.