Patent · US Active

Method for synthesizing lactam derivatives without use of catalyst

US11884628B2 · kind B2 · utility

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1References
5Claims
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Key dates

Filing dateAug 22, 2019
Grant dateJan 30, 2024
Priority date—
Expiry dateJan 5, 2040

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D409/04
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Disclosed is a simple synthesis method of lactam derivatives, comprising: with formamide functioning as both an amine source and a hydrogen source (hydrolyzed to produce formic acid), carrying out a cycloamination reaction on a raw material keto acid in the absence of a solvent or a catalyst to simply synthesize a lactam derivative. Compared with previous reports, the present disclosure has the following advantages: the time required for the reaction is greatly shortened, the selectivity is remarkably improved, a conversion rate of a keto acid derivative is greater than 99%, and the yield of the lactam derivative can reach 70% to 94%.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.