Immunoglobulin binding protein, and affinity support using same
US11884705B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 25, 2018 |
| Grant date | Jan 30, 2024 |
| Priority date | — |
| Expiry date | May 15, 2040 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2220/52
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Provided are a protein L-derived immunoglobulin binding protein having an increased antibody dissociation rate under acidic conditions, and an affinity support using the same. Disclosed are an immunoglobulin binding protein comprising at least one mutant of an immunoglobulin binding domain, and an affinity support comprising a solid-phase support having the immunoglobulin binding protein bound thereto. A mutant of the immunoglobulin binding domain consists of an amino acid sequence having an identity of at least 85% with the sequence set forth in any one of SEQ ID NO:1 to SEQ ID NO:9 and a predetermined mutation, and the mutant has immunoglobulin κ chain binding activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.