Patent · US Active

Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof

US11884944B2 · kind B2 · utility

2Cited by

15References

39Claims

0Family size

Assignee

DENALI THERAPEUTICS INC. · US

Inventors

Tina GIESE · South San Francisco, US
Gunasekaran Kannan · Daly City, US
Mihalis Kariolis · South San Francisco, US
Cathal S. Mahon · San Francisco, US

Key dates

Filing date	Jun 30, 2022
Grant date	Jan 30, 2024
Priority date	—
Expiry date	Jun 30, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise sulfoglucosamine sulfohydrolase (SGSH) enzyme-Fc fusion polypeptides. Certain embodiments also provide methods of using such proteins to treat Sanfilippo syndrome A.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.