Steroid acid-peptide based cytotoxic compounds
US11890350B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Nov 16, 2022 |
| Grant date | Feb 6, 2024 |
| Priority date | — |
| Expiry date | Nov 16, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/09
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Agents having cytotoxic activity, as well as compositions, uses, and methods relating thereto, are described herein. Certain steroid acid-peptide conjugates or moieties have the ability to induce killing or inhibition of proliferation of mammalian cells, in vitro or in vivo upon administration to a subject. The steroid acid-peptide conjugates include bile acids and bile acid analogs and peptides that may include a nuclear localisation signal or a portion thereof. Also described herein is a method for treating cancer, an autoimmune disease, or any other disease or disorder ameliorated by treatment with an antiproliferative drug in a subject in a subject with the cytotoxic agents described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.