Patent · US Active

Processes for the preparation of furazanobenzimidazoles and crystalline forms thereof

US11891382B2 · kind B2 · utility

1Cited by

3References

32Claims

0Family size

Assignee

Basilea Pharmaceutica International AG · CH

Inventors

Gregor Welti · Basel, CH
Markus Heubes · Kaarst, DE
David Tagliaferri · Basel, CH

Key dates

Filing date	Apr 24, 2018
Grant date	Feb 6, 2024
Priority date	—
Expiry date	Nov 30, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides processes for preparing a compound of formula (I) and pharmaceutically acceptable salts thereof, comprising deprotecting a compound of formula (II), wherein each R3 independently represents a tertiary alkyl group, preferably wherein each R3 is tertiary butyl. The invention also provides intermediates useful for preparing compounds of formula (I) and processes for preparing these intermediates. Additionally the invention provides polymorphic forms of the dichloride salt of the compound of formula (I) and their use in the treatment of proliferative disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.