Compositions and methods for treating age-related diseases

US11891442B2 · kind B2 · utility

Assignees

• The Board of Trustees of the Leland Stanford Junior University · US
• United States Government as represented by the Department of Veterans Affairs · US

Inventors

• Anton Wyss-Coray · Palo Alto, US
• John Vincent Pluvinage · Atherton, US
• Michael C. Bassik · Stanford, US
• Michael Haney · Stanford, US
• Benjamin Smith · Belmont, US
• Carolyn R. Bertozzi · Berkeley, US

Key dates

• Filing date: Dec 21, 2018
• Grant date: Feb 6, 2024
• Expiry date: Dec 21, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16044
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.