Method to enhance the transcription regulation of SUPT4H on genes containing repetitive nucleotide sequences
US11891601B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Jan 22, 2019 |
| Grant date | Feb 6, 2024 |
| Priority date | — |
| Expiry date | May 1, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method of modulating the expression of a gene containing expanded nucleotide repeats in a cell, comprising: inhibiting the biological activity of SPT4 or SUPT4H; and regulating the formation of R-loops. The inhibition step can effectively reduce the expression of the gene containing the expanded nucleotide repeats and the regulatory step can further enhance the inhibition step. The inhibition step and the regulation step are for the purpose of regulating gene expression by interfering the capacity of RNA polymerase II transcribing over a DNA template with lengthy nucleotide repeats.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.