Transcription activator-like effector (tale) - lysine-specific demethylase 1 (LSD1) fusion proteins

US11891631B2 · kind B2 · utility

Assignee

• The General Hospital Corporation · US

Inventors

• Jae Keith Joung · Winchester, US
• Eric Mendenhall · Rancho Santa Margarita, US
• Bradley E. Bernstein · Cambridge, US
• Deepak Reyon · Malden, US

Key dates

• Filing date: Apr 5, 2019
• Grant date: Feb 6, 2024
• Expiry date: Oct 18, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/63
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array (TALE) or zinc finger array, and a catalytic domain comprising a sequence that catalyzes histone demethylation, and methods of use thereof.