Time-varying kinetic modeling of high temporal-resolution dynamic pet data for multiparametric imaging
US11896417B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 8, 2019 |
| Grant date | Feb 13, 2024 |
| Priority date | — |
| Expiry date | Apr 27, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2576/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Systems and methods are disclosed for quantifying blood flow using time-varying kinetic modeling of high temporal-resolution dynamic positron emission tomography (PET) data. A single tracer is introduced into the body. A first set of images is acquired, via PET, of at least a portion of the body at a plurality of predetermined time intervals. Based on the first set of images, an intensity of the tracer in the at least the portion of the body is determined as a function of time. The intensity of the tracer as a function of time is modeled using a time-varying kinetic model. Based on the model, the blood flow through the at least the portion of the body is quantified. Additional images may be acquired and used to quantify additional parameter(s), such as glucose metabolism, amyloid load, etc., with the single tracer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.