Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells

US11896614B2 · kind B2 · utility

Assignees

• Novartis AG · CH
• The Trustees of the University of Pennsylvania · US

Inventors

• David Barrett · Philadelphia, US
• Felipe Bedoya · Tampa, US
• Saba Ghassemi · Philadelphia, US
• Carl H. June · Yeadon, US
• Bruce L. Levine · Cherry Hill, US
• Jan J. Melenhorst · Cherry Hill, US
• Michael C. Milone · Cherry Hill, US
• Daniel J. Powell, Jr. · Bala-Cynwyd, US
• Nathan Amar Singh · Philadelphia, US
• Zoe Zheng · Cherry Hill, US

Key dates

• Filing date: Apr 15, 2016
• Grant date: Feb 13, 2024
• Expiry date: Sep 25, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/2318
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.