Conjugation method for carrier-linked prodrugs

US11896671B2 · kind B2 · utility

Assignee

• ASCENDIS PHARMA A/S · DK

Inventors

• Nicola Bisek · Heidelberg, DE
• Samuel Weisbrod · Heidelberg, DE
• Kornelia Bigott · Mannheim, DE

Key dates

• Filing date: Jul 12, 2017
• Grant date: Feb 13, 2024
• Expiry date: Dec 3, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to reagents comprising a substituted acyl borate or a substituted hydroxylamine, to a method of synthesizing a carrier-linked prodrug using said reagents and to carrier-linked prodrugs obtainable by said method.