Azaspirocycles as monoacylglycerol lipase modulators

US11897872B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Jesus Alcazar · Toledo, ES
• Michael K. Ameriks · San Diego, US
• Cynthia B. Berry · Poway, US
• Pablo Garcia-Reynaga · San Diego, US
• Andrew V. Samant · San Diego, US
• J. A. Vega-Ramiro · Toledo, ES

Key dates

• Filing date: Oct 31, 2022
• Grant date: Feb 13, 2024
• Expiry date: Oct 31, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Azaspirocycle compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions: wherein X, R1, R2a, R2b, R3, m, n, o, and p are defined herein.