Anti-PSGL-1 antibodies and uses thereof

US11897964B2 · kind B2 · utility

Assignee

• AltruBio Inc. · US

Inventors

• Stefan Bassarab · Biberach, DE
• Barbara Enenkel · Warthausen, DE
• Patrick Garidel · Norderstedt, DE
• Heidrun Schott · Schemmerhofen, DE
• Sanjaya Singh · Sandy Hook, US
• Tobias Litzenburger · Mittelbiberach, DE

Key dates

• Filing date: Aug 30, 2021
• Grant date: Feb 13, 2024
• Expiry date: Aug 30, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein, in one aspect, are antibodies that immunospecifically bind to PSGL-1, polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to PSGL-1, as well as methods of treating a disorder or disease caused by or associated with increased proliferation and/or numbers of activated T cells using the antibodies described herein.