Covalent inhibitors of equine encephalitis virus
US11905249B2 · kind B2 · utility
0Cited by
7References
18Claims
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Key dates
| Filing date | Jan 25, 2021 |
| Grant date | Feb 20, 2024 |
| Priority date | — |
| Expiry date | Jan 25, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D241/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Embodiments and methods for a new class of potent non-peptidic covalent inhibitors of nsP2 cysteine protease that inhibit Venezuelan equine encephalitis virus's (VEEV) replication in neuroblasts are disclosed. More particularly, an acrylate and vinyl sulfone-based chemical series were investigated as promising starting scaffolds against VEEV and as inhibitors of the cysteine protease domain of VEEV's non-structural protein 2 (nsP2). The invention discloses compounds of Formula I and analogues for treatment of VEEV.
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