Solid state forms of (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide and uses thereof

US11905255B1 · kind B1 · utility

Assignee

• PFIZER INC. · US

Inventors

• Elaine Greer · Groton, US
• Stephen Anderson · Stonington, US
• Mark Maloney · East Lyme, US
• Shu Yu · Xiangcheng District, CN
• Ekaterina Albert · West Lafayette, US
• Emily Rigsbee · West Lafayette, US

Key dates

• Filing date: Jul 28, 2023
• Grant date: Feb 20, 2024
• Expiry date: Jul 28, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.