Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus

US11905306B2 · kind B2 · utility

Assignees

• Southern Research Institute · US
• VANDERBILT UNIVERSITY · US
• The University of North Carolina at Chapel Hill · US

Inventors

• Syed Kaleem Ahmed · Hoover, US
• Shilpa Dutta · Birmingham, US
• John Phillip Tillotson · Birmingham, US
• Corinne E. Augelli-Szafran · Homewood, US
• Ashish Kumar Pathak · Macomb, US
• Omar Moukha-Chafiq · Birmingham, US
• Timothy Patrick Sheahan · Chapel Hill, US
• Ralph Baric · Haw River, US
• Amy Catherine Sims · Richland, US
• Mark R. Denison · Nashville, US

Key dates

• Filing date: Dec 21, 2022
• Grant date: Feb 20, 2024
• Expiry date: Dec 21, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.