Compound chimeric antigen receptor (cCAR) targeting multiple antigens, compositions and methods of use thereof

US11905528B2 · kind B2 · utility

Assignee

• iCell Gene Therapeutics LLC · US

Inventors

• Yupo Ma · Las Vegas, US
• Kevin PINZ · Stony Brook, US
• Xun JIANG · Stony Brook, US
• Masayuki Wada · Stony Brook, US
• Kevin Chen · Beijing, CN

Key dates

• Filing date: Oct 12, 2018
• Grant date: Feb 20, 2024
• Expiry date: Jan 17, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2510/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one embodiment, the present disclosure provides an engineered cell having a first chimeric antigen receptor polypeptide including a first antigen recognition domain, a first signal peptide, a first hinge region, a first transmembrane domain, a first costimulatory domain, and a first signaling domain; and a second chimeric antigen receptor polypeptide including a second antigen recognition domain, a second signal peptide, a second hinge region, a second transmembrane domain, a second co-stimulatory domain, and a second signaling domain; wherein the first antigen recognition domain is different than the second antigen recognition domain.