Two-photon stimulated emission depletion composite microscope using continuous light loss

US11906429B2 · kind B2 · utility

Assignees

• Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences · CN
• SUZHOU GUOKE MEDICAL TECHNOLOGY DEVELOPMENT (GROUP) CO., LTD. · CN

Inventors

• Yunhai Zhang · Suzhou, CN
• Yuguo Tang · 安丰镇, CN
• Tongda Wei · 安丰镇, CN
• Jian Chang · Suzhou, CN
• Haomin Yang · 安丰镇, CN
• Lin Ji · Nanhu, CN

Key dates

• Filing date: Nov 27, 2018
• Grant date: Feb 20, 2024
• Expiry date: Oct 30, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G02B21/082
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A two-photon stimulated emission depletion composite microscope using continuous light loss, the microscope comprising: a two-photon imaging unit (100) and an STED imaging unit (200), wherein for thicker samples, the two-photon imaging unit (100) can be used, and for regions of interest on the surface of samples, the STED super-resolution imaging unit (200) can be used. The two-photon stimulated emission depletion composite microscope using continuous light loss integrates two functions of STED imaging and two-photon imaging, so as to provide a powerful tool for cutting-edge biomedical research.