Fatty acid synthase inhibitor and application thereof

US11911353B2 · kind B2 · utility

Assignee

• Jiangnan University · CN

Inventors

• Yongquan Chen · Wuxi, CN
• Hongyan Qu · Wuxi, CN
• Chunlei Tang · Wuxi, CN
• Guosheng Wu · Beijing, CN
• Guozhen Cui · Beijing, CN
• Ninghan Feng · Wuxi, CN
• Xiaoying Wang · Hummelstown, US
• Kai SHAN · Wuxi, CN
• Shenglong Zhu · Shenyang, CN
• Lengyun Wei · Wuxi, CN

Key dates

• Filing date: Oct 30, 2020
• Grant date: Feb 27, 2024
• Expiry date: Dec 3, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure discloses a fatty acid synthase inhibitor and application thereof and belongs to the technical field of medical biology. The fatty acid synthase inhibitor of the disclosure can significantly inhibit the activity of fatty acid synthase without affecting normal expression, and adjust the ratio of fatty acids in cells. The fatty acid synthase inhibitor of the disclosure has a good tumor proliferation inhibitory effect, can arrest the growth cycle of tumor cells in the interphase, prevent tumor cell division, inhibit tumor cell proliferation, promote tumor cell apoptosis and exert a tumor treatment effect, can be used to treat tumors and metabolism related diseases, and has an important clinical application prospect.