Biphenyl diaryl pyrimidine derivative with aromatic heterocyclic structure

US11912685B2 · kind B2 · utility

Assignee

• FUDAN UNIVERSITY · CN

Inventors

• Fener CHEN · Shanghai, CN
• Chunlin Zhuang · Shanghai, CN
• Li Ding · Singapore, SG

Key dates

• Filing date: Sep 7, 2021
• Grant date: Feb 27, 2024
• Expiry date: Sep 7, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This application provides a biphenyl diaryl pyrimidine derivative with an aromatic heterocyclic structure, a pharmaceutically-acceptable salt, a stereoisomer, a hydrate and a solvate thereof, where the biphenyl diaryl pyrimidine derivative is shown in formula (I). This application also provides a pharmaceutical composition containing the biphenyl diaryl pyrimidine derivative, or a pharmaceutically-acceptable salt, a stereoisomer, a hydrate and a solvate thereof, and a pharmaceutically-acceptable carrier. This application further provides a method of treating AIDS by administering a therapeutically effective amount of the pharmaceutical composition to a patient in need.