Compositition and uses of teleost invariant chain to enhance T cell response to a vaccine
US11912743B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 2, 2018 |
| Grant date | Feb 27, 2024 |
| Priority date | — |
| Expiry date | Aug 28, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/10371
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polypeptides comprising a fragment of a teleost invariant chain fused to one or more antigens can enhance T cell response. Alternatively a teleost invariant chain fused to one or more antigens or antigenic fragments thereof can be used. A polynucleotide encoding such polypeptides, vectors comprising such polynucleotides, collection of vectors comprising such polynucleotides are also disclosed. The use of such polypeptides, polynucleotides, vectors for treating or preventing diseases, in particular tumor diseases are also encompassed by the present invention. The teleost invariant chain polypeptides or fragments thereof act as “T cell enhancer” converting non-immunogenic antigenic sequences into immunogenic T cell antigens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.