Antigen-specific T cells and uses thereof
US11913025B2 · kind B2 · utility
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Key dates
| Filing date | Mar 29, 2018 |
| Grant date | Feb 27, 2024 |
| Priority date | — |
| Expiry date | Mar 24, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/998
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are methods of inducing differentiation and/or proliferation of T cells and uses thereof. In the present method, peripheral blood mononuclear cells (PBMCs) isolated from a subject are cultivated with bi-specific antibodies (BsAbs) in a culture medium so as to differentiate the PBMCs into the T cells. Each of the T cells has an anti-tumor antigen moiety and an anti-CD3 moiety on its surface. Also provided are methods and pharmaceutical kits for treating subjects suffering from cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.