Continuous flow method for preparing (R)-3-hydroxy-5-hexenoate

US11913055B2 · kind B2 · utility

Assignee

• FUDAN UNIVERSITY · CN

Inventors

• Fener CHEN · Shanghai, CN
• Dang CHENG · Shanghai, CN
• Zedu Huang · Shanghai, CN
• Chen-Ze Hu · Keelung, TW
• Meifen JIANG · Shanghai, CN
• Minjie LIU · Shanghai, CN
• Huashan HUANG · Shanghai, CN

Key dates

• Filing date: Oct 19, 2021
• Grant date: Feb 27, 2024
• Expiry date: Mar 22, 2042

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/50
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed herein relates to biopharmaceuticals, and more particularly to a continuous flow method for preparing (R)-3-hydroxy-5-hexenoate. Carbonyl reductase and isopropanol dehydrogenase are co-immobilized onto an inert solid medium simultaneously to prepare a carbonyl reductase/isopropanol dehydrogenase co-immobilized catalyst, which is then filled into a microchannel reactor of the micro reaction system. A solution containing substrate 3-carbonyl-5-hexenoate is subsequently pumped into the microchannel reactor to perform an asymmetric carbonyl reduction reaction to obtain (R)-3-hydroxy-5-hexenoate.