Microfluidic chip device for optical force measurements and cell imaging using microfluidic chip configuration and dynamics
US11913870B2 · kind B2 · utility
1Cited by
8References
28Claims
0Family size
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Key dates
| Filing date | Jan 26, 2022 |
| Grant date | Feb 27, 2024 |
| Priority date | — |
| Expiry date | Jan 26, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2015/1493
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided are methods and devices for assessing biological particles for use in cell immunotherapy. By utilizing a microfluidic chip device together with optical force measurement and cell imaging, the methods enable comprehensive assessment and characterization of biological particles with regard to morphology, motility, binding affinities, and susceptibility to external forces, including but not limited to, chemical, biochemical, biological, physical and temperature influences. The methods enable the selection and production of biological particles, such as engineered T-cells, for use in immunotherapy and biomanufacturing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.