Pyrazole pyrimidine compounds and uses thereof

US11918582B2 · kind B2 · utility

Assignee

• RAPT THERAPEUTICS, INC. · US

Inventors

• Cyril Bucher · San Mateo, US
• Adrian Dukes · South San Francisco, US
• Blanca Gomez · South San Francisco, US
• Hannah Haley · South San Francisco, US
• Dennis X. Hu · San Mateo, US
• Jeffrey J. Jackson · San Bruno, US
• Michelle Yoo Min Ko · San Francisco, US
• Paul Robert Leger · Oakland, US
• Anqi Ma · New York, US
• Andrew A. Ng · South San Francisco, US
• Daniel Poon · Piedmont, US
• Omar Robles · Waco, US
• Anton Shakhmin · Santa Clara, US
• Grant Shibuya · South San Francisco, US
• Parcharee Tivitmahaisoon · San Francisco, US
• Vi-Anh Vu · South San Francisco, US
• David Juergen Wustrow · Ann Arbor, US
• Mikhail Zibinsky · Redwood City, US

Key dates

• Filing date: Mar 14, 2022
• Grant date: Mar 5, 2024
• Expiry date: Mar 14, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.