Low concentrated protein compositions for preventing tissue adhesion

US11918629B2 · kind B2 · utility

Assignee

• Omrix Biopharmaceuticals Ltd. · IL

Inventors

• Israel Nur · Afula, IL
• Elena Grimberg · Rehovot, IL
• Itai Podoler · Rehovot, IL
• Inbar Gahali-Sass · Mazkeret Batya, IL
• Erez Ilan · Nezer Sereni, IL
• Ronen Eavri · Binyamina - Givat Ada, IL

Key dates

• Filing date: Dec 11, 2019
• Grant date: Mar 5, 2024
• Expiry date: Dec 11, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2400/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are kits comprised of a first container including a solution of fibrinogen-containing component that includes fibrinogen at a concentration range of about 5 mg/ml to about 30 mg/ml, and having a total protein concentration range of about 15 mg/ml to about 40 mg/ml; and a second container that includes a solution of thrombin-containing component. Further provided are mixtures comprised of fibrinogen and thrombin, calcium ions, and albumin, the mixture being comprised of total protein in a range of about 2.5 mg/ml to about 30 mg/ml, fibrinogen in a range of about 50% to about 80% of total protein, and albumin in a range of more than 0.65 mg/ml to about 3 mg/ml. Further provided herein are methods for preventing or reducing tissue adhesion, and hydrogel materials made of fibrin.