Compositions and methods for enhancing the biological response to chemical agents and physical stimuli

US11918822B2 · kind B2 · utility

Assignees

• The Research Foundation for The State University of New York · US
• The University of North Carolina at Chapel Hill · US

Inventors

• Clinton Rubin · Port Jefferson, US
• Janet Rubin · Chapel Hill, US

Key dates

• Filing date: Oct 19, 2022
• Grant date: Mar 5, 2024
• Expiry date: Oct 19, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N5/062
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.