Array of micro-elements for high resolution and high content imaging and sorting of cells

US11920115B2 · kind B2 · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• Cell Microsystems, Inc · US

Inventors

• Nancy Allbritton · Irvine, US
• Yuli Wang · Lynnwood, US
• Christopher Sims · Irvine, US
• Nicholas C. Dobes · Durham, US
• Steven C. Gebhart · Durham, US
• Nicholas Trotta · San Francisco, US

Key dates

• Filing date: Aug 29, 2018
• Grant date: Mar 5, 2024
• Expiry date: Aug 29, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12M41/36
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

An array of magnetic or paramagnetic micro-elements comprised of polysilsesquioxane is described having ultra-low-autofluorescence and other optical properties to improve microscopic imaging of cells or other objects present on the array. These materials are also amenable to chemical modification allowing surface attachment of affinity capture moieties or chemical reporters for selective binding or analysis of cells, macromolecules or other targets.