Perfusable-type dual proximal tubule cell construct and producing method thereof for applying in vitro artificialrenal tissue model and renal cell therapy
US11925726B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 18, 2020 |
| Grant date | Mar 12, 2024 |
| Priority date | — |
| Expiry date | Jun 30, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2502/28
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present disclosure is related to a perfusable-type bio-dual proximal tubule cell construct and a producing method thereof capable of applying an in vitro artificial organ model configured to include a first bioink comprising a decellularized substance derived from a mammalian kidney tissue and human umbilical vascular endothelial cells (HUVECs) and a second bioink comprising the decellularized substance and renal proximal tubular epithelial cells (RPTECs), wherein the first bioink and the second bioink are coaxial and printed in tubular constructs having different inner diameters.According to the present disclosure, it is possible to use the renal proximal tubule-on-a-chip as a bioreactor capable of observing a biological drug reaction similar to a real drug by perfusing various drugs to the renal proximal tubule-on-a-chip.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.