Certain pladienolide compounds and methods of use
US11926619B2 · kind B2 · utility
0Cited by
1References
18Claims
0Family size
Assignee
Inventors
- Gregg F. Keaney
- John Wang
- Baudouin Gérard
- Kenzo Arai
- Xiang LIU
- Guo Zhu Zheng
- Kazunobu Kira
- Lisa A. Marcaurelle
- Marta Nevalainen
- Ming-Hong Hao
- Morgan Welzel O'Shea
- Parcharee Tivitmahaisoon
- Sudeep Prajapati
- Tuoping Luo
- Nicholas C. Gearhart
- Jason T. Lowe
- Yoshihiko Kotake
- Satoshi Nagao
- Regina Mikie Kanada Sonobe
- Masayuki Miyano
- Norio Murai
- Andrew Cook
- Shelby ELLERY
- Atsushi Endo
- James Palacino
- Dominic Reynolds
Key dates
| Filing date | Apr 8, 2019 |
| Grant date | Mar 12, 2024 |
| Priority date | — |
| Expiry date | Jul 2, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/107
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.