Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates
US11931414B2 · kind B2 · utility
0Cited by
16References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 27, 2018 |
| Grant date | Mar 19, 2024 |
| Priority date | — |
| Expiry date | Dec 20, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.